1) Draw an annotated diagram of a diploid cell with four chromosomes undergoing meiosis and show two
ways that non-disjunction can occur. Indicate the kind of chromosome anomalies that can arise in a zygote formed by fertilisation with each of the resulting gametes and one normal gamete.

2) Draw an annotated diagram of two chromosomes showing that one of them has experienced two
double-strand breaks. Draw the possible chromosomal rearrangements that might occur when the fragments of the broken chromosome are re-joined.