22 year old male presents for an evaluation his history is significant for opiate use disorder the patient abuses 1g of heroin intravenously daily the last dose of heroin was two hours ago the patient denies any restlessness nausea vomiting or diarrhea his vital signs included blood pressure 120 / 80 pulse 72 respiratory rate 18 and the temperature is 98.6° the physical exam was normal the patient wants to stop heroin and asks for medication-assisted treatment which one of the following medications may cause precipitated withdrawal if it starts at this point
a) buprenorphine
B) Clonidine
C) methadone
D) LofeXidine



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