Which of the following is true about aldosterone?
A. Its main site of action is the P-cell of the proximal tubule of the nephron.
B. None of the above statements are true.
C. The release of aldosterone is stimulated by low plasma [K+].
D. Aldosterone is a hormone that is released by the zona glomerulosa of the adrenal medulla.
E. It is generally released in response to low blood pressure or very high plasma osmolarity.