An individual who has recently been prescribed a drug to lower cholesterol levels is advised to limit consumption of grapefruit juice, because its high intake reportedly results in an increased level of the statin in the blood, increasing the risk of adverse reactions. This particular statin is a substrate for the cytochrome P450 enzyme CYP3A4. Which statement concerning CYP enzymes is most likely correct? They:
O Accept electrons from reduced nicotinamide adenine dinucleotide
O Catalyze the hydroxylation of hydrophobic molecules
O Differ from nitric oxide synthase in that they contain heme
O Function in association with an oxidate