What was the effect of the Declaration of Helsinki?

Responses

It put an end to global unethical research practices on humans.
It put an end to global unethical research practices on humans.

It led to further developments that discouraged unethical studies.
It led to further developments that discouraged unethical studies.

It made unethical human research illegal and punishable by law.
It made unethical human research illegal and punishable by law.

It gave a utilitarian explanation for unethical studies on humans.