Which of the following statements about enzyme mechanism reaction steps are true (select all that apply) ?
A. On a reaction coordinate diagram, a reversible step is indicated by reactant and product at similar energy
B. Irreversible steps are important in enzyme mechanisms to help ensure enzymes catalyze reactions in the desired direction
C. Substrate binding is usually an irreversible step
D. Irreversible steps of a reaction mechanism are always very slow
E. To determine if a step is reversible or irreversible, it is necessary to know the activation energy of the step