MandieRayl2899 MandieRayl2899 28-04-2024 Health Answered Once the saline enema fluid is inside Mrs. Lopez's rectum, how long will Rosie ask her to keep it in? 1) Follow the package or doctor's instructions. 2) Usually about 10 minutes. 3) Two hours, at minimum. 4) At least one, if not two, hours.