How do Nrf2 and Keap1 regulate the cellular response to oxidative stress?
1) O Stress degrades Nrf2, allowing Keap1 to function as a transcription factor.
2) Stressors stabilize Nrf2 by disrupting its interaction with Keap1.
3) Nrf2, upon activation, forms a complex with Keap1 in the nucleus.
4) Keap1 binds to Nrf2 and promotes its nuclear translocation.