How do memory B cells arise? How do memory B cells arise? They are B cells that have undergone class switching to express cell surface IgE. They are a special subset of B cells that mature in the spleen. They arise from progeny of activated B cells that have undergone somatic hypermutation and class switching. They arise from long-lived plasma cells and continue to produce antibodies. They arise from the bone marrow after activated B cells signal to produce more B cells that recognize the same antigen