Some viruses like HERV integrate into human genomes and continually create havoc for the cells and the tissue. How could the cell heritably silence the region of genome in which the virus integrated, so that the cell could continue to live and do well?
O Use CRISPR/Cas9 to make a mutation in the viral DNA
O Inhibit RNA polymerase II, so that the viral DNA could use that enzyme to make viral RNA and proteins.
O Use a microRNA to make a mutation in the enhancer, so that it could evolve a away from that virus.
O Methylate the DNA around the viral insertion site
O De-methylate the DNA around the viral insertion site.