Which of the following are correct regarding the pharmacology of substance abuse disorders other than alcohol and nicotine? Select all that apply.
a. Overdose produces a classic triad of symptoms: respiratory depression, coma, and pinpoint pupils. Naloxone [Narcan], an opioid antagonist, is the treatment of choice.
b. Buprenorphine [Suboxone] is an agonist-antagonist opioid used to treat opioid use disorder but is restricted to Opioid Treatment Programs approved by the designated state authority and certified by the federal Substance Abuse and Mental Health Services Administration.
c. Heroin has a high lipid solubility, crosses the blood-brain barrier with ease, and causes effects that are both immediate and intense
d. In an effort to reduce OxyContin abuse, the controlled-release tablets were reformulated in 2010