Summarize: Angelman syndrome is a genetic disorder that causes significant disabilities. Students diagnosed with this syndrome generally present in the classroom with a lack of oral language, significant developmental delay, a uniquely cheerful personality, and challenges with motor control and motor coordination. This project reviews the literature on Angelman syndrome in order to explain the learning characteristics we would expect to see in these students in the areas of communication, cognition, physical abilities, sensory abilities, affect, attention, and unique medical needs. These learning characteristics are summarized along with a review of instructional approaches that may be appropriate to assist educators to meet the needs of these students. Next, the literature review is summarized in fact sheets collected in an informational booklet for educators. The fact sheets suggest specific instructional strategies to assist educators to meet the needs of students with Angelman syndrome. Finally, the project concludes with a description of how families and educators can re-imagine the needs of students with Angelman syndrome to maximize opportunities for these students to participate in regular classrooms and to access instruction in the general education curriculum.