An 85-year-old patient has been seeing the APN for 5 years. Based on yearly blood work, the APN notes that the patient's creatinine clearance (CrCl) is decreased, as has his estimated glomerular filtration rate (eGFR). These levels are new, because the patient has always had CrCl and eGFR close to normal limits. How does this change in his laboratory work affect the patient's risk for ADRs?

a. The APN should stop all of the patient's drugs immediately until more tests of renal function can be completed and more is known about potential ADRs.
b. Most drugs are cleared through the kidneys and therefore the APN should review drugs being taken to see if adjustments in dosages should be made to reduce the risk of ADRs.
c. It decreases his risk, because he will not clear drugs as quickly and therefore they will have more of an opportunity to work in the body.
d. These two laboratory values have little to do with drug clearance, and therefore do not affect drug metabolism in the body or ADRs.
b. Most drugs are cleared through the kidneys and therefore the APN should review drugs being taken to see if adjustments in dosages should be made to reduce the risk of ADRs.