Compound X is a weak acid that has two ionizable protons. The pKa values for the protons are 2.5 and 7.2. The molecule starts out with a net charge of 2 at pH 2 and below and the charge is due to the protonation state of the ionizable protons. What is the likely net charge at pH 6? pH 10? You can use approximations for your answer. Uncharged molecules are more diffusive in biological systems through lipid bilayer membranes. Assuming that blood is buffered at pH 7.4 will this molecule be more or less diffusive across biological membranes in higher animals? No need for a concrete number here – estimates are fine.