Which of the following statements about chromatin structure and function are correct?
A. Histone acetylation opens chromatin by reducing the positive electrical charge of histone proteins
B. Histone methylation closes chromatin by increasing the positive electrical charge of histone proteins
C. Chromatin state varies with the cell cycle but is uniform across chromosomes and genes
D. Chromatin states do not persist when a cell goes through mitosis and must be re-established each cell cycle
E. Methylation of histone tail residues cause closed chromatin regardless of which specific amino acid is methylated
F. Acetylation of histone tail residues cause open chromatin regardless of which specific amino acid is acetylated