Integrins ___ (Select all that apply):
a. are often hyperactive in cancer cells, enabling cell migration to new tissues.
b. are made of 1 alpha and 1 beta subunit, which clump together and fold when inactive.
c. can connect to the ECM to hold the cell at a certain location.
d. can transmit information from the environment to the cell, which may lead to changes in cell adhesion or differentiation.
e. can transmit information from the cell to the environment, which may lead to changes in cell adhesion or differentiation.