Which of the following is the best definition of autoimmune disease?

A. A condition in which a molecule belonging to the host is treated like an antigen and triggers an immune response
B. A condition in which the acquired immune system fails to recognize the second infection by the same antigen
C. A condition in which the immune system creates random antibodies without being triggered by an antigen
D. A condition in which B cells and T cells respond independently to antigens and do not interact correctly