Ahmad,55 years 55-year-old male, a patient with diabetes mellitus, who has had poorly controlled hypertension, and now presents with signs of ankle edema & a low GFR. He was prescribed the following drugs in the last three months but BP values are still uncontrolled.
1. Propranolol.
2. Amlodipine.
3. Hydrochlorothiazide.
4. Metformin (Hypoglycemic drug).
Which one of the listed drugs is highly associated to his ankle edema?