A 52-year-old woman feels a lump in her right breast on elf-examination and goes to her physician. On physical examination the 4 cm mass is not freely movable and feels quite hard. A fine needle aspirate is performed and cytologic examination shows cells are present consistent with carcinomA. Which of the following features of this carcinoma is most likely to suggest a worse prognosis?
a. Estrogen receptor positivity
b. Family history of breast carcinoma
c. Presence of an in-situ component
d. Axillary lymph node metastases
e. Lack of aneuploidy