In anesthesia, the dose of drug administered is often based on the patient’s total body weight and is usually given as milligrams per kilogram of body weight. However, adjustments may have to be made for some drugs. For example, for drugs that are maintained primarily within the ____________ compartment and have a small volume of distribution, the dose of drug administered will be based on lean body weight. This is because the drug is not fat-soluble and in an obese patient, it will not move into the fat compartment. In this case, basing the drug dose on total body weight may lead to ____________.

a. vascular; underdosing
b. vascular; overdose
c. fat; underdosing
d. fat; overdose