The stages of acute inflammation precede the process of cutaneous wound healing. Arrange the following statements in the correct for how these two processes will cause healing to occur.
A. Vasoconstriction quickly occurs to encourage clotting and control of bleeding first. This is immediately followed by vasodilation which brings inflammatory cells to the wound.
B. Fibroblasts are the first to proliferate building connective tissue and secrete collagen. This is followed by epithelial cells proliferation that migrate to close the wound.
C. Collagen production needs to be controlled. Collagenase will lyse this ECM protein to remodel tissue at the wound. This activity will help reestablish healthy tissue and control scar tissue formation.
D. Inflammatory cells (leukocytes) will now arrive at the wound site. These cells then transmigrate through the vessels to enter the interstitum to begin the cellular phase of inflammation.