Which of the following statements IS TRUE about protein folding:
A. Diseases like Alzheimers, Parkinsons, bovine spongiform ecephalopathy (BSE), kuru, Creutzfeld-Jacob disease (CJD) and new variant CJD (nvCJD) are all caused by viruses and bacteria that make human proteins misfold
B. Alzheimers arises when a protein called amyloid precursor protein (APP) that is a normal constituent of many healthy cells is converted to Amyloid () by proteolytic cleavage of APP; Amyloid once formed starts polymerizing into large fibers of alpha helices that cause aggregates that induce neuronal apoptosis (brain cell death)
C. A prion is an infectious misfolded protein. A bad (misfolded) prion (eg. PrPSC) can induce a correctly folded (harmless) version of it (eg. PrPC) into misfolding into the bad form (PrPSC).
D. Proteins that help other proteins fold in vivo are called chaperones (also called Heat Shock Proteins or HSPs); An example of a chaperone is the chaperonin ribonuclease .