A mutation in a collagen gene is likely to affect the phenotype because

A. It is extremely rare.
B. People who use cosmetics with collagen silence collagen genes.
C. Collagen has a very precise three-dimensional structure, so nearly any disruption alters the overall conformation.
D. During meiosis, the chromosome that bears the mutation is more likely to enter a gamete than the chromosome that carries the wild type allele.