For an E2 reaction to occur, the leaving group and the proton to be removed typically must be anti to each other. This is called an anticoplanar arrangement and is a crucial piece of information to consider when you are predicting products of E2 reactions. The E2 pathway is favored by relatively hindered substrates with good leaving groups when such substrates are combined with strong bases. In this exercise, you'll draw the mechanism and product of the E2 reaction of (1S,2S)-1-chloro-1-phenyl-2-methylhexane with the strong base, sodium ethoxide.