1. Jamestown is founded as an English colony in Virginia.
2. Americans defeat British forces at Yorktown with help from France.
3. Spanish conquest destroys the Aztec civilization.
4. The Constitutional Convention is called in Philadelphia.
The first event that took place out of these options was the Spanish Conquest that destroyed the Aztec Civilization which was in 1519. Therefore the correct sequence is 3,1,2,4.