Answer:
The correct answer is option C. chromosome replication.
Explanation:
The cell cycle involves interphase and M- phase (mitosis or meiosis). DNA or chromosome replication takes place in interphase before Mitosis or meiosis phase of the cell cycle.
The replicated chromosomes are already present before mitosis initiation. Spindle formation takes place in the prophase of the mitotic. Centromere takes place in the shortest stage of mitosis which is anaphase.
Thus, the correct is option C. chromosome replication.