Answer :
The differences between the North and South were great both socially, economically, and politically. It is difficult to see the institution of slavery being ended in the South without the threat of violence or actual violence. The institution of slavery was believed to be integral to the Southern economy that it is hard to imagine it going away through compromise at that point in history.
It is unlikely that any compromise or political debate could have prevented the Civil War. The North was intent on maintaining the strength of the Union, which would have remained at risk if the issue of slavery was ignored. On the other hand, the South depended completely on slavery. As they were reliant on agriculture and this required slave labour, they could not have emancipated the slaves without completely destroying their economy. It is unlikely that any politician would have seen this as a good alternative.
The great divide between their industrialization levels was also a significant problem. Even if the South were to become more industrial, the change would have been a difficult one, and it is unlikely it would have been achieved without enormous economic disruption.