The major road that Interstate 40 roughly follows is the **C) Natchez Trace**. The Natchez Trace Parkway is a historical route that stretches from Natchez, Mississippi to Nashville, Tennessee. Interstate 40 follows a similar path to the Natchez Trace Parkway, allowing travelers to follow a modern highway along the historic route.
By following the Natchez Trace, Interstate 40 provides a scenic and historically significant journey for those traveling between the same destinations as the original Natchez Trace route. This alignment allows for both practical transportation and the opportunity to appreciate the cultural and natural heritage of the region.