Which of the following may be caused in part by a deficiency in folic acid, a B-vitamin present in green leafy vegetables, dried beans, liver, orange juice, and grapefruit juice?
1) Phenylketonuria and hypothyroidism
2) German Measles (Rubella)
3) Tay-Sachs disease and Down Syndrome
4) Anencephaly and Spina Bifida