The correct answer is:
- It can be difficult to know if humans should interfere to protect endangered species.
Explanation:
1. When creating nature preserves, one common issue is the dilemma of whether humans should intervene to protect endangered species. This is a complex ethical and ecological question that conservationists often grapple with.
2. While it's important to preserve biodiversity and protect endangered species, deciding the extent of human intervention in natural processes can be challenging.
3. The other options provided in the question suggest that problems such as interference in natural processes and the placement of preserves in areas with high biodiversity can indeed be issues when creating and managing protected land.