The first confrontation between the Minutemen and British troops took place in Lexington.
Here's a brief overview of the event:
1. On April 19, 1775, in Lexington, Massachusetts, British troops marched to confiscate colonial weapons and arrest Samuel Adams and John Hancock.
2. A small group of Minutemen, American colonial militia members, faced the British troops near Lexington Green.
3. The confrontation escalated, leading to the famous "shot heard 'round the world," marking the beginning of the American Revolutionary War.
Therefore, the correct answer to the question is C. Lexington.