Please select the correct statement:
A) Mouse monoclonal antibodies are not antigenic in humans. A mouse monoclonal antibody can be used for in vivo treatment of patients with cancer many times without concerns of inducing an anti-mouse antibody, because of the high homology of mouse and human immunoglobulins.
B) Although many monoclonal antibodies are specific for single antigenic epitopes, a large number of monoclonal antibodies recognize multiple antigenic epitopes.
C) A human-murine chimeric monoclonal antibody is, in general, an antibody constructed by fusing the antigen binding region, VH and VL, from a mouse antibody with the constant domain, Fc region, from human immunoglobulin.