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5. Hyperkalemia reduces the excitability of neurons and muscle cells. Which of the following
best describes the effect of increased extracellular potassium [K],?
A. Depolarizes the cell, thus reducing action potential amplitude
B. Depolarizes the cell, thus inactivating voltage-gated Na+ channels
C. Hyperpolarizes the cell, which increases the action potential threshold
D. Increases the activity of the Na-K-ATPase, which hyperpolarizesthe cell
E. Stimulates endocytosis of Na+ channels



Answer :

GinnyAnswer
In the context of increased extracellular potassium [K] levels, the effect on the cell can be described as follows: A. Depolarizes the cell, thus reducing action potential amplitude When extracellular potassium levels increase (hyperkalemia), it disrupts the normal concentration gradient across the cell membrane. This disrupts the resting membrane potential and can lead to cell depolarization. Depolarization can reduce the action potential amplitude by affecting the ability of neurons and muscle cells to generate electrical signals effectively. This altered electrical activity can impact the normal functioning of these cells and reduce excitability.

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