Answer :
The most rare subgroup of lung cancer among the options provided is Mesothelioma. Mesothelioma is a type of cancer that affects the mesothelial cells which line the organs like the lungs, abdomen, or heart. It is primarily linked to asbestos exposure and is relatively uncommon compared to other types of lung cancer.
Here is a breakdown of the options provided:
1. Non-small cell lung cancer: This is the most common type of lung cancer and includes subtypes like adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
2. Mesothelioma: As mentioned earlier, mesothelioma is rare and typically associated with asbestos exposure.
3. Small cell lung cancer: This is a type of lung cancer that grows quickly and is less common than non-small cell lung cancer but more common than mesothelioma.
4. Adenocarcinoma: This is a subtype of non-small cell lung cancer and is one of the most common forms of lung cancer.
In summary, among the options provided, Mesothelioma is considered the most rare subgroup of lung cancer due to its association with asbestos exposure and its relatively low occurrence compared to other types like non-small cell lung cancer and its subtypes.