Chromosomal mutations involve significant changes in chromosome structure or number, while point mutations are alterations in a single nucleotide. Understanding the differences between these mutations is crucial in genetics.
Chromosomal mutations involve changes in the structure or number of chromosomes, such as deletions, duplications, insertions, inversions, and translocations. These mutations can have serious effects, sometimes resulting in death or developmental abnormalities, as seen in Down Syndrome.
Point mutations, on the other hand, are changes in a single nucleotide in DNA, which can be silent, missense, or nonsense mutations. They are typically less severe than chromosomal alterations and may involve substitutions, insertions, or deletions of nucleotides.
Examples of chromosomal mutations include deletions removing chromosome segments, duplications inserting extra segments, inversions flipping segments, and translocations moving segments between chromosomes.
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