Based on the given numbers, we can estimate that the numbers 1 to 8 occurred 24 times out of the 30 generated numbers.
Using the formula for estimating the probability of a certain event occurring,
Probability (event) = (Number of favorable outcomes) / (Total number of possible outcomes)
In this case, the number of favorable outcomes is 8 (the numbers representing the medicine being effective), and the total number of possible outcomes is 30.
So, the estimated probability of the medicine being effective on fewer than two of the next three patients is: