Final answer:
Tolerance refers to the decrease in the action of a drug with repeat exposure, requiring higher doses for the same effect.
Explanation:
Tolerance is the ability to endure unusually large doses of a substance without ill effect. It refers to a decrease in the action of a drug due to repeat exposure, resulting in the need for higher doses to achieve the same effect. This phenomenon is often seen with various drugs, leading to the necessity for a higher dosage to experience the same physiological and psychological effects.
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