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Which of the following pharmacokinetic processes may highly reduce the bioavailability of a drug?
A) Topical administration
B) The concentration of red blood cells
C) First-pass metabolism from the liver
D) Kidney filtration



Answer :

C

C) First-pass metabolism from the liver

First-pass metabolism refers to the metabolism of a drug in the liver before it enters the systemic circulation. This process can greatly reduce the bioavailability of a drug as a significant portion of the drug may be metabolized and rendered inactive before reaching the bloodstream.

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