In the renin-angiotensin system, the organs that play a significant role in producing hormones or enzymes are the kidney and the heart.
1. Kidney: The kidney produces an enzyme called renin. Renin is released by special cells in the kidneys in response to low blood pressure or low sodium levels. Renin acts as the starting point in the renin-angiotensin system by converting angiotensinogen (produced by the liver) into angiotensin I.
2. Heart: The heart is involved in the renin-angiotensin system through the release of a hormone called atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF). This hormone is produced by cells in the heart's atria (upper chambers) in response to high blood pressure. ANP helps to regulate blood pressure and fluid balance by promoting vasodilation (widening of blood vessels) and increasing sodium excretion by the kidneys.
So, the correct organs that produce hormones or enzymes in the renin-angiotensin system are the kidney and the heart.