Based on the information provided from the TRUS biopsy of the prostate, the Gleason score is a system used to grade prostate cancer based on how abnormal the cancer cells look under a microscope. The Gleason score is determined by adding together the two most common grades of cancer cells seen in the biopsy samples.
In this case, the Gleason scores from the biopsy cores are as follows:
- 1 core with Gleason 4 + 4 = 8
- 3 cores with Gleason 4 + 3 = 7
- 1 core with Gleason 3 + 3 = 6
The highest Gleason score is 8, which is from the core with Gleason 4 + 4. Therefore, the clinical grade of the prostate cancer based on the biopsy results would be Gleason score 8.