Ribosome
2-
mRNA
Figure 3. Production of a-MSH in keratinocytes in response to UV radiation
Which of the following claims best explains why keratinocytes do not produce melanin?
Keratinocytes do not contain the TYR, TRP2, and TRP1 genes.
B
Keratinocytes do not contain the MC1R gene.
C
Keratinocytes do not express the MITF gene.
Keratinocytes do not express the POMC gene.



Answer :

Final answer:

Keratinocytes do not produce melanin due to the absence of POMC gene expression.


Explanation:

The best explanation for why keratinocytes do not produce melanin is that keratinocytes do not express the POMC gene. When ultraviolet light activates p53 in skin cells, it initiates transcription of the gene encoding POMC, leading to the production of melanocyte-stimulating hormone (MSH). This MSH stimulates melanocytes to produce melanin, but keratinocytes do not directly produce melanin themselves.


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