Answer:
C. Chronic kidney disease
Explanation:
Methotrexate is a medication that is commonly used to cure specific types of cancer, autoimmune diseases, and inflammatory conditions. It works by inhibiting the metabolism of folic acid, which is necessary for the synthesis of DNA, RNA, and proteins. With the options provided, Chronic kidney disease (C. Chronic kidney disease) is a recognized potential late effect of methotrexate. Methotrexate can cause renal toxicity, which may lead to chronic kidney disease over time, especially if not monitored and managed properly.