The Spanish conquest of Mesoamerica resulted in the decimation of native populations due to exposure to European diseases.
The major effect of the Spanish conquest of Mesoamerica was the decimation of native populations exposed to European diseases. Prior to the arrival of Europeans, Amerindians lacked immunity to diseases like smallpox and influenza, leading to a drastic decline in their numbers. This devastating impact reshaped the demographic landscape of Middle America.
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