Final answer:
The spread of the Islamic Empire and the start of the transatlantic slave trade are two significant events in the African history before 1600 CE.
Explanation:
The most significant event in the history of Africa before 1600 CE according to the reading is the spread of the Islamic Empire across North Africa starting in the 7th century CE. This event brought about profound cultural and religious changes, shaping the course of African history. The transatlantic slave trade that commenced in the 15th century CE also had a major impact on Africa's cultural landscape and history, albeit slavery being present prior to European involvement.
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