Answer :

When punctuating lists in a sentence, it is indeed best practice to use commas when separating items if there are 2 or more items in the list. This helps in ensuring clarity and readability. For example:

1. If you have a simple list with 2 items:
- "I bought apples and oranges."
Notice the use of 'and' to separate the two items without a comma.

2. If there are 3 or more items in the list:
- "I bought apples, oranges, and bananas."
Here, commas are used to separate the items, with an additional comma before the 'and' (known as the Oxford comma) to further clarify the separation of the items.

Therefore, the true answer for this question is:

True