Schedule I drugs are highly addictive with severe health risks and no medical applications, while Schedule V drugs have low addiction potential and legitimate clinical uses.
Schedule I drugs are substances perceived to have the highest addiction potential, severe health risks, and no medical applications (e.g., heroin). Schedule V substances have low addiction potential, few health risks, and legitimate clinical uses (e.g., Lyrica). The Controlled Substances Act categorizes illegal drugs into schedules based on their harmful or addictive qualities.
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