Final answer:
Loop diuretics affect salt excretion in the kidneys, leading to increased urination.
Explanation:
Loop Diuretics Mechanism and Effect
Loop diuretics inhibit the reabsorption of Na+ and Cl- ions by the ascending limb of the loop of Henle in the kidneys. This action leads to a decrease in salt excretion into the renal medulla, reducing its osmolality and ultimately causing an increase in urination.
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