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Which of the following are mechanisms by which cancer cells develop resistance to B-raf inhibitors? (Select all that apply)
Group of answer choices
A. Mutations in MEK, downstream of Raf
B. Overexpression of other Raf isoforms
C. Mutation in Ras
D. Activation of a different signaling pathway (pathway different from Ras/Raf/MEK pathway)



Answer :

Answer:

The mechanisms by which cancer cells can develop resistance to B-Raf inhibitors include:

A. Mutations in MEK, downstream of Raf

B. Overexpression of other Raf isoforms

C. Mutation in Ras

D. Activation of a different signaling pathway (pathway different from Ras/Raf/MEK pathway)

All of the listed options are mechanisms by which cancer cells can develop resistance to B-Raf inhibitors. Resistance can occur through various means, including mutations downstream of Raf in the MAPK pathway, upregulation of alternate Raf isoforms, activating mutations in Ras, and activation of parallel signaling pathways that can bypass the inhibition of B-Raf.

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