Frameshift mutations result from nucleotide insertions or deletions, causing significant changes in the protein's amino acid sequence.
Frameshift mutations occur due to the insertion or deletion of nucleotides in DNA, leading to a shift in the reading frame used by ribosomes during translation. This results in a significant change in the amino acid sequence of the protein being synthesized.
Insertions or deletions that alter the reading frame may cause a frameshift mutation, where the triplet codon sequence is disrupted, affecting the entire downstream sequence of amino acids.
Frameshift mutations can have profound effects on protein structure and function, highlighting the importance of maintaining the correct reading frame during translation.
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