Final answer:
Topoisomerases and single-strand binding proteins are key players in correcting DNA supercoiling during replication.
Explanation:
Topoisomerases play a crucial role in correcting supercoiling of DNA during replication. These enzymes relieve the topological stress by cutting and swiveling DNA strands before rejoining them, thereby preventing the DNA from getting twisted on itself.
Supercoiling occurs as the DNA unwinds during replication, generating positive supercoils ahead of the replication fork. Topoisomerases produce breaks in the DNA and then rejoin them to form negative supercoils, effectively relieving the stress in the DNA molecule.
Single-strand binding proteins also contribute by coating the DNA around the replication fork to prevent rewinding, helping to maintain the separation of the DNA strands.
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